Title |
TNA4OptFlux – a software tool for the analysis of strain optimization strategies
|
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Published in |
BMC Research Notes, May 2013
|
DOI | 10.1186/1756-0500-6-175 |
Pubmed ID | |
Authors |
José P Pinto, Rui Pereira, João Cardoso, Isabel Rocha, Miguel Rocha |
Abstract |
Rational approaches for Metabolic Engineering (ME) deal with the identification of modifications that improve the microbes' production capabilities of target compounds. One of the major challenges created by strain optimization algorithms used in these ME problems is the interpretation of the changes that lead to a given overproduction. Often, a single gene knockout induces changes in the fluxes of several reactions, as compared with the wild-type, and it is therefore difficult to evaluate the physiological differences of the in silico mutant. This is aggravated by the fact that genome-scale models per se are difficult to visualize, given the high number of reactions and metabolites involved. |
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Mendeley readers
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