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Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression

Overview of attention for article published in BMC Neuroscience, January 2009
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Title
Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression
Published in
BMC Neuroscience, January 2009
DOI 10.1186/1471-2202-10-2
Pubmed ID
Authors

Lenneke WA van Hooijdonk, Muhammad Ichwan, Thomas F Dijkmans, Theo G Schouten, Marijke WA de Backer, Roger AH Adan, Fons J Verbeek, Erno Vreugdenhil, Carlos P Fitzsimons

Abstract

In the adult hippocampus, the granule cell layer of the dentate gyrus is a heterogeneous structure formed by neurons of different ages, morphologies and electrophysiological properties. Retroviral vectors have been extensively used to transduce cells of the granule cell layer and study their inherent properties in an intact brain environment. In addition, lentivirus-based vectors have been used to deliver transgenes to replicative and non-replicative cells as well, such as post mitotic neurons of the CNS. However, only few studies have been dedicated to address the applicability of these widespread used vectors to hippocampal cells in vivo. Therefore, the aim of this study was to extensively characterize the cell types that are effectively transduced in vivo by VSVg-pseudotyped lentivirus-based vectors in the hippocampus dentate gyrus.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 1%
United States 2 1%
Norway 1 <1%
Ireland 1 <1%
Switzerland 1 <1%
Canada 1 <1%
Germany 1 <1%
Russia 1 <1%
United Kingdom 1 <1%
Other 0 0%
Unknown 125 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 29%
Researcher 31 23%
Student > Master 14 10%
Student > Doctoral Student 8 6%
Student > Bachelor 8 6%
Other 21 15%
Unknown 15 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 68 50%
Neuroscience 21 15%
Medicine and Dentistry 8 6%
Biochemistry, Genetics and Molecular Biology 8 6%
Business, Management and Accounting 2 1%
Other 8 6%
Unknown 21 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2013.
All research outputs
#20,194,150
of 22,711,242 outputs
Outputs from BMC Neuroscience
#1,052
of 1,241 outputs
Outputs of similar age
#164,049
of 169,756 outputs
Outputs of similar age from BMC Neuroscience
#16
of 18 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,756 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.