Title |
Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG
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Published in |
Acta Neuropathologica Communications, May 2013
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DOI | 10.1186/2051-5960-1-18 |
Pubmed ID | |
Authors |
Anna C Navis, Simone P Niclou, Fred Fack, Daniel Stieber, Sanne van Lith, Kiek Verrijp, Alan Wright, Jonathan Stauber, Bastiaan Tops, Irene Otte-Holler, Ron A Wevers, Arno van Rooij, Stefan Pusch, Andreas von Deimling, Wikky Tigchelaar, Cornelis JF van Noorden, Pieter Wesseling, William PJ Leenders |
Abstract |
Point mutations in genes encoding NADP+-dependent isocitrate dehydrogenases (especially IDH1) are common in lower grade diffuse gliomas and secondary glioblastomas and occur early during tumor development. The contribution of these mutations to gliomagenesis is not completely understood and research is hampered by the lack of relevant tumor models. We previously described the development of the patient-derived high-grade oligodendroglioma xenograft model E478 that carries the commonly occurring IDH1-R132H mutation. We here report on the analyses of E478 xenografts at the genetic, histologic and metabolic level. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
United Kingdom | 1 | 1% |
Unknown | 73 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 22% |
Student > Ph. D. Student | 16 | 21% |
Student > Master | 12 | 16% |
Other | 5 | 7% |
Student > Doctoral Student | 5 | 7% |
Other | 12 | 16% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 25 | 33% |
Medicine and Dentistry | 18 | 24% |
Agricultural and Biological Sciences | 14 | 18% |
Neuroscience | 3 | 4% |
Chemistry | 3 | 4% |
Other | 4 | 5% |
Unknown | 9 | 12% |