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Survival following gamma knife radiosurgery for brain metastasis from breast cancer

Overview of attention for article published in Radiation Oncology, May 2013
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Title
Survival following gamma knife radiosurgery for brain metastasis from breast cancer
Published in
Radiation Oncology, May 2013
DOI 10.1186/1748-717x-8-131
Pubmed ID
Authors

Jerry J Jaboin, Daniel J Ferraro, Todd A DeWees, Keith M Rich, Michael R Chicoine, Joshua L Dowling, David B Mansur, Robert E Drzymala, Joseph R Simpson, William J Magnuson, Anushka H Patel, Imran Zoberi

Abstract

Breast cancer is the second most common cause of brain metastases in the United States. Although breast cancer induced brain metastases represent an incurable condition, some patients experience prolonged survival. In this retrospective study, we examine a cohort of patients with brain metastases from breast cancer treated with Gamma Knife stereotactic radiosurgery to identify factors that predict better outcomes. A retrospective database of 100 patients treated for brain metastases due to breast cancer via Gamma Knife radiosurgery (GKS) from July 1998 through March 2009 was reviewed. Patients who received radiosurgery as sole treatment, as a planned boost after whole brain radiotherapy or surgical resection, or as salvage after prior whole brain radiation therapy (WBRT) or surgical resection were included. Prognostic factors identified to be significant for survival in previous brain metastasis studies were analyzed for significance by univariate and multivariate Cox analysis. Overall, the median brain progression-free survival time was 7.1 months and the median survival time was 12.3 months. No prognostic variables were significant for brain progression-free survival. For patients treated with a planned GKS after WBRT, GKS as sole treatment, GKS salvage after WBRT, GKS boost after surgery, or GKS for surgical salvage the median survival times (MSTs) were as follows: 12.2 months, 12.4 months, 9.5 months, 27.6 months and 33.4 months respectively. Differences between the groups were not significant (p = 0.06); however, GKS boost after surgery and GKS for salvage after surgery did have a trend toward better overall survival. Stereotactic radiosurgery offers good local control and prolonged survival in selected patients. Age and number of lesions are strong predictors of overall survival.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 17%
Student > Bachelor 6 13%
Student > Ph. D. Student 5 10%
Student > Postgraduate 5 10%
Student > Master 3 6%
Other 8 17%
Unknown 13 27%
Readers by discipline Count As %
Medicine and Dentistry 18 38%
Agricultural and Biological Sciences 4 8%
Physics and Astronomy 3 6%
Nursing and Health Professions 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 5 10%
Unknown 14 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2013.
All research outputs
#17,689,426
of 22,711,242 outputs
Outputs from Radiation Oncology
#1,274
of 2,046 outputs
Outputs of similar age
#139,552
of 195,178 outputs
Outputs of similar age from Radiation Oncology
#32
of 47 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,046 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.