Title |
Hamartomatous polyposis syndromes
|
---|---|
Published in |
Hereditary Cancer in Clinical Practice, June 2013
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DOI | 10.1186/1897-4287-11-4 |
Pubmed ID | |
Authors |
Zoran Stojcev, Pawel Borun, Jacek Hermann, Piotr Krokowicz, Wojciech Cichy, Lukasz Kubaszewski, Tomasz Banasiewicz, Andrzej Plawski |
Abstract |
Hamartomas are tumour-like malformations, consisting of disorganized normal tissues, typical of the site of tumour manifestation. Familial manifestation of hamartomatous polyps can be noted in juvenile polyposis syndrome (JPS), Peutz-Jeghers' syndrome (PJS), hereditary mixed polyposis syndrome (HMPS) and PTEN hamartoma tumour syndrome (PHTS). All the aforementioned syndromes are inherited in an autosomal dominant manner and form a rather heterogenous group both in respect to the number and localization of polyps and the risk of cancer development in the alimentary tract and other organs. Individual syndromes of hamartomatous polyposis frequently manifest similar symptoms, particularly during the early stage of the diseases when in several cases their clinical pictures do not allow for differential diagnosis. The correct diagnosis of the disease using molecular methods allows treatment to be implemented earlier and therefore more effectively since it is followed by a strict monitoring of organs that manifest a predisposition for neoplastic transformation. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 16% |
Other | 2 | 11% |
Student > Bachelor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Other | 2 | 11% |
Unknown | 6 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 47% |
Agricultural and Biological Sciences | 3 | 16% |
Arts and Humanities | 1 | 5% |
Unknown | 6 | 32% |