Title |
Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids
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Published in |
Molecular Pain, January 2013
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DOI | 10.1186/1744-8069-9-26 |
Pubmed ID | |
Authors |
Alexandra Higgins, Sharleen Yuan, Yanqing Wang, Brian D Burrell |
Abstract |
Although a number of clinical and preclinical studies have demonstrated analgesic effects of cannabinoid treatments, there are also instances when cannabinoids have had no effect or even exacerbated pain. The observed pro-nociceptive effects appear to be due to cannabinoid-induced disinhibition of afferent synaptic input to nociceptive circuits. To better understand how cannabinoid-mediated plasticity can have both pro- and anti-nociceptive effects, we examined the possibility that cannabinoids differentially modulate nociceptive vs. non-nociceptive synapses onto a shared postsynaptic target. These experiments were carried out in the central nervous system (CNS) of the medicinal leech, in which it is possible to intracellularly record from presynaptic nociceptive (N-cell) or pressure-sensitive (P-cell) neurons and their shared postsynaptic targets. |
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