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CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

Overview of attention for article published in BMC Neuroscience, January 2017
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Title
CX3C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke
Published in
BMC Neuroscience, January 2017
DOI 10.1186/s12868-016-0325-0
Pubmed ID
Authors

Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch, Karsten Ruscher

Abstract

The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also been shown to be important in the regulation of the inflammatory response in the early phase after experimental stroke. The present study was performed to investigate if CX3CR1 deficiency affects microglia during the first 14 days with consequences for tissue damage after experimental stroke. CX3CR1 deficiency significantly increased the number of intersections of GFP positive microglia in the proximal peri-infarct area at 2, 7 and 14 days following tMCAO compared to heterozygous and wildtype littermates. In addition, the length of microglial branches increased until day 7 in CX3CR1 knockout mice while the presence of a functional CX3CR1 allele resulted in a gradual reduction of their length following tMCAO. After stroke, wildtype, heterozygous and CX3CR1 deficient mice did not show differences in the composite neuroscore and assessment of infarct volumes from CX3CR1 wildtype, heterozygous and deficient mice revealed no differences between the genotypes 7 and 14 days after stroke. Results demonstrate that CX3CR1 deficiency affects the morphology of GFP positive microglia located in the proximal peri-infarct region during the first 14 days after tMCAO. Our data also indicate that CX3CR1 deficiency does not affect definite infarct volumes. Modulation of the CX3CR1 pathway may have implication for microglia function contributing to mechanisms of tissue reorganization in the post-ischemic brain.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 26%
Student > Master 6 19%
Student > Ph. D. Student 6 19%
Professor 2 6%
Student > Bachelor 1 3%
Other 5 16%
Unknown 3 10%
Readers by discipline Count As %
Neuroscience 12 39%
Agricultural and Biological Sciences 5 16%
Biochemistry, Genetics and Molecular Biology 2 6%
Immunology and Microbiology 2 6%
Nursing and Health Professions 1 3%
Other 3 10%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2017.
All research outputs
#9,169,230
of 10,444,782 outputs
Outputs from BMC Neuroscience
#787
of 936 outputs
Outputs of similar age
#257,450
of 314,659 outputs
Outputs of similar age from BMC Neuroscience
#16
of 34 outputs
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