Title |
Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group
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Published in |
BMC Cancer, June 2013
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DOI | 10.1186/1471-2407-13-276 |
Pubmed ID | |
Authors |
Sonia Cellot, Donna Johnston, David Dix, Marie-Chantal Ethier, Biljana Gillmeister, David Mitchell, Rochelle Yanofsky, Victor Lewis, Carol Portwine, Victoria Price, Shayna Zelcer, Mariana Silva, Lynette Bowes, Bruno Michon, Kent Stobart, Josee Brossard, Joseph Beyene, Lillian Sung |
Abstract |
BACKGROUND: It is not known whether children with acute promyelocytic leukemia (APL) have an infection risk similar to non- APL acute myeloid leukemia. The objective was to describe infectious risk in children with newly diagnosed APL and to describe factors associated with these infections. METHODS: We conducted a retrospective, population-based cohort study that included children <= 18 years of age with de novo APL treated at 15 Canadian centers. Thirty-three children with APL were included; 78.8% were treated with APL -specific protocols. RESULTS: Bacterial sterile site infection occurred in 12 (36.4%) and fungal sterile site infection occurred in 2 (6.1%) children. Of the 127 chemotherapy courses, 101 (79.5%) were classified as intensive and among these, the proportion in which a sterile site microbiologically documented infection occurred was 14/101 (13.9%). There was one infection-related death. CONCLUSIONS: One third of children with APL experienced at least one sterile site bacterial infection throughout treatment and 14% of intensive chemotherapy courses were associated with a microbiologically documented sterile site infection. Infection rates in pediatric APL may be lower compared to non- APL acute myeloid leukemia although these children may still benefit from aggressive supportive care during intensive chemotherapy. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 19% |
Researcher | 4 | 15% |
Student > Postgraduate | 3 | 12% |
Student > Ph. D. Student | 2 | 8% |
Other | 2 | 8% |
Other | 3 | 12% |
Unknown | 7 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 62% |
Agricultural and Biological Sciences | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Unknown | 7 | 27% |