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A case of GABAR antibodies in schizophrenia

Overview of attention for article published in BMC Psychiatry, January 2017
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Title
A case of GABAR antibodies in schizophrenia
Published in
BMC Psychiatry, January 2017
DOI 10.1186/s12888-016-1157-2
Pubmed ID
Authors

Ida S. Haussleiter, Klaus-Peter Wandinger, Georg Juckel

Abstract

In the last couple of years, schizophrenia was often discussed as autoimmune disease. Several antibodies were suspected, but so far there has been no proof of Gamma-aminobutyric acid (GABA) receptor antibodies in patients with schizophrenia. In this case report we present a 21-year old woman with schizophrenic symptoms, who showed anti-GABAB1 antibodies when screened by a vast recombinant neurology mosaic on Human Embryonic Kidney Cells 293 (HEK293) cells. The young woman presented with various psychotic symptoms as well as speech and motor ataxia, with the neurological signs starting in childhood. A hypofunction of the GABAergic system is a possible cause of severe schizophrenic symptoms. Postmortem studies proved this hypothesis by showing dysfunctional GABAergic interneurons in various brain areas. Therefore one should always think of an immune-mediated pathogenesis as well memory impairment and behavioral changes co-occur with frequent seizures.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 22%
Student > Bachelor 8 20%
Researcher 4 10%
Student > Postgraduate 2 5%
Student > Ph. D. Student 2 5%
Other 5 12%
Unknown 11 27%
Readers by discipline Count As %
Medicine and Dentistry 10 24%
Neuroscience 9 22%
Psychology 4 10%
Nursing and Health Professions 2 5%
Immunology and Microbiology 2 5%
Other 2 5%
Unknown 12 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2018.
All research outputs
#17,489,487
of 25,654,806 outputs
Outputs from BMC Psychiatry
#4,022
of 5,502 outputs
Outputs of similar age
#270,637
of 425,130 outputs
Outputs of similar age from BMC Psychiatry
#66
of 82 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,502 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,130 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.