Title |
Colchicine triggered severe rhabdomyolysis after long-term low-dose simvastatin therapy: a case report
|
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Published in |
Journal of Medical Case Reports, January 2017
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DOI | 10.1186/s13256-016-1169-z |
Pubmed ID | |
Authors |
Clara Frydrychowicz, Bastian Pasieka, Matthias Pierer, Wolf Mueller, Sirak Petros, Lorenz Weidhase |
Abstract |
Rhabdomyolysis is a widely recognized yet rare complication in statin use. Rhabdomyolysis might be triggered by the prescription of high doses of statins or by statin accumulation due to interactions with concomitant medication. Muscle cell destruction as evidenced by myoglobin elevation can induce potentially life-threatening acute renal failure. We report a case of a 70-year-old obese white man with sudden onset of severe rhabdomyolysis with consecutive renal failure. His medication included low-dose simvastatin, which he had taken for 6 years up until the event. The statin was withdrawn immediately. After 3 days of veno-venous hemofiltration his renal function was completely restored. Clinicians in both primary and special care might be unaware that side effects of statins do occur even after a long uneventful statin medication; they should be advised not to exclude that possibility upfront, even if a patient has tolerated the medication for years. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Members of the public | 1 | 33% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 17% |
Student > Postgraduate | 5 | 14% |
Student > Master | 4 | 11% |
Researcher | 4 | 11% |
Student > Ph. D. Student | 3 | 8% |
Other | 5 | 14% |
Unknown | 9 | 25% |
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Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 31% |