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Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress

Overview of attention for article published in BMC Medicine, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
blogs
2 blogs
twitter
87 tweeters
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
127 Dimensions

Readers on

mendeley
258 Mendeley
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Title
Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress
Published in
BMC Medicine, January 2017
DOI 10.1186/s12916-016-0771-7
Pubmed ID
Authors

Aadil Bharwani, M. Firoz Mian, Michael G. Surette, John Bienenstock, Paul Forsythe

Abstract

Stress-related disorders involve systemic alterations, including disruption of the intestinal microbial community. Given the putative connections between the microbiota, immunity, neural function, and behaviour, we investigated the potential for microbe-induced gut-to-brain signalling to modulate the impact of stress on host behaviour and immunoregulation. Male C57BL/6 mice treated orally over 28 days with either Lactobacillus rhamnosus (JB-1) ™ or vehicle were subjected to chronic social defeat and assessed for alterations in behaviour and immune cell phenotype. 16S rRNA sequencing and mass spectrometry were employed to analyse the faecal microbial community and metabolite profile. Treatment with JB-1 decreased stress-induced anxiety-like behaviour and prevented deficits in social interaction with conspecifics. However, JB-1 did not alter development of aggressor avoidance following social defeat. Microbial treatment attenuated stress-related activation of dendritic cells while increasing IL-10+ regulatory T cells. Furthermore, JB-1 modulated the effect of stress on faecal metabolites with neuroactive and immunomodulatory properties. Exposure to social defeat altered faecal microbial community composition and reduced species richness and diversity, none of which was prevented by JB-1. Stress-related microbiota disruptions persisted in vehicle-treated mice for 3 weeks following stressor cessation. These data demonstrate that despite the complexity of the gut microbiota, exposure to a single microbial strain can protect against certain stress-induced behaviours and systemic immune alterations without preventing dysbiosis. This work supports microbe-based interventions for stress-related disorders.

Twitter Demographics

The data shown below were collected from the profiles of 87 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 258 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 54 21%
Student > Master 50 19%
Student > Ph. D. Student 35 14%
Researcher 28 11%
Student > Doctoral Student 18 7%
Other 31 12%
Unknown 42 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 17%
Neuroscience 42 16%
Medicine and Dentistry 33 13%
Biochemistry, Genetics and Molecular Biology 28 11%
Psychology 12 5%
Other 42 16%
Unknown 57 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2019.
All research outputs
#469,188
of 20,832,759 outputs
Outputs from BMC Medicine
#363
of 3,060 outputs
Outputs of similar age
#13,266
of 416,215 outputs
Outputs of similar age from BMC Medicine
#30
of 213 outputs
Altmetric has tracked 20,832,759 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,215 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 213 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.