Title |
Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia
|
---|---|
Published in |
Medical Gas Research, June 2013
|
DOI | 10.1186/2045-9912-3-11 |
Pubmed ID | |
Authors |
Ahmad Ghanizadeh, Michael Berk |
Abstract |
Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered for treating bipolar disorder has effects on oxidative stress and apoptotic pathways, as do valproate and some atypical antipsychotics for treating schizophrenia. Molecular hydrogen has been studied pre-clinically in animal models for the treatment of some medical conditions including hypoxia and neurodegenerative disorders, and there are intriguing clinical findings in neurological disorders including Parkinson's disease. Therefore, it is hypothesized that administration of hydrogen molecule may have potential as a novel therapy for bipolar disorder, schizophrenia, and other concurrent disorders characterized by oxidative, inflammatory and apoptotic dysregulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 17% |
United States | 3 | 17% |
India | 1 | 6% |
Unknown | 11 | 61% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 17 | 94% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 20% |
Student > Ph. D. Student | 7 | 16% |
Student > Master | 7 | 16% |
Lecturer | 3 | 7% |
Student > Postgraduate | 3 | 7% |
Other | 11 | 25% |
Unknown | 4 | 9% |
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Agricultural and Biological Sciences | 6 | 14% |
Neuroscience | 4 | 9% |
Veterinary Science and Veterinary Medicine | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Other | 7 | 16% |
Unknown | 8 | 18% |