Solid-state stability study of meropenem – solutions based on spectrophotometric analysis

Judyta Cielecka-Piontek, Magdalena Paczkowska, Kornelia Lewandowska, Boleslaw Barszcz, Przemyslaw Zalewski, Piotr Garbacki

B-Lactam antibiotics are still the most common group of chemotherapeutic drugs that are used in the treatment of bacterial infections. However, due to their chemical instability the potential to apply them as oral pharmacotherapeutics is often limited and so it is vital to employ suitable non-destructive analytical methods. Hence, in order to analyze such labile drugs as β-lactam analogs, the application of rapid and reliable analytical techniques which do not require transferring to solutions or using organic solvents, following the current green approach to pharmaceutical analysis, is necessary. The main objective of the present research was to develop analytical methods for the evaluation of changes in meropenem in the solid state during a stability study.