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Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation

Overview of attention for article published in BMC Cardiovascular Disorders, June 2013
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Title
Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation
Published in
BMC Cardiovascular Disorders, June 2013
DOI 10.1186/1471-2261-13-40
Pubmed ID
Authors

Rui Providência, Ana Faustino, Luís Paiva, Andreia Fernandes, Sérgio Barra, Joana Pimenta, Joana Trigo, Ana Botelho, António M Leitão-Marques

Abstract

BACKGROUND: Mean platelet volume has been associated with stroke in patients with atrial fibrillation. However, its role as a predictor of left atrial stasis, assessed by transesophageal echocardiography, in patients with non-valvular atrial fibrillation has not yet been clarified. METHODS: Single center cross-sectional study comprising 427 patients admitted to the emergency department due to symptomatic atrial fibrillation and undergoing transesophageal echocardiogram evaluation for exclusion of left atrial appendage thrombus before cardioversion. All patients had a complete blood count performed in the 12 hours prior to transesophageal echocardiogram. Markers of left atrial stasis were sought: left atrial appendage thrombus, dense spontaneous echocardiographic contrast and low flow velocities in the left atrial appendage. The presence of at least one of the former markers of left atrial stasis was designated left atrial abnormality. Binary logistic multivariate analysis was used for obtaining models for the prediction of transesophageal echocardiogram endpoints. RESULTS: Left atrial appendage thrombus was found in 12.2%, dense spontaneous echocardiographic contrast in 29.7%, low flow velocities in 15.3% and left atrial abnormality in 34.2%. Mean platelet volume (exp beta = 3.41 p = 0.048) alongside with previous stroke or transient ischemic attack (exp beta = 5.35 p = 0.005) and troponin I (exp beta = 5.07 p = 0.041) were independent predictors of left atrial appendage thrombus. Mean platelet volume was also incorporated in the predictive models of dense spontaneous echocardiographic contrast, low flow velocities and left atrial abnormality, adding predictive value to clinical, echocardiographic and laboratory variables. CONCLUSIONS: These findings suggest that mean platelet volume may be associated with the presence of markers of left atrial stasis, reinforcing a likely cardioembolic mechanism for its association with stroke in patients with non-valvular atrial fibrillation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Master 4 15%
Other 3 11%
Student > Bachelor 3 11%
Student > Postgraduate 2 7%
Other 2 7%
Unknown 7 26%
Readers by discipline Count As %
Medicine and Dentistry 12 44%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Immunology and Microbiology 1 4%
Computer Science 1 4%
Psychology 1 4%
Other 1 4%
Unknown 10 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2013.
All research outputs
#18,340,012
of 22,711,645 outputs
Outputs from BMC Cardiovascular Disorders
#1,097
of 1,594 outputs
Outputs of similar age
#148,279
of 197,423 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#11
of 19 outputs
Altmetric has tracked 22,711,645 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,594 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.