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Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

Overview of attention for article published in Biology Direct, June 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#45 of 600)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
1 news outlet
twitter
21 tweeters

Citations

dimensions_citation
152 Dimensions

Readers on

mendeley
239 Mendeley
citeulike
1 CiteULike
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Title
Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions
Published in
Biology Direct, June 2013
DOI 10.1186/1745-6150-8-12
Pubmed ID
Authors

Arsen O Batagov, Igor V Kurochkin

Abstract

Small secreted membrane vesicles called exosomes have recently attracted a great interest after the discovery that they transfer mRNA that can be translated into protein in recipient cells. Surprisingly, we found that for the majority of exosomal mRNAs only a fraction of their corresponding probes is detectable on the expression microarrays. Exosomal mRNA fragmentation is characterized with a specific structural pattern. The closer to the 3'-end of the transcript the fragments are localized, the larger fraction among the secreted RNAs they constitute. Since the 3'-ends of transcripts contain elements conferring subcellular localization of mRNA and are rich in miRNA-binding sites, exosomal RNA may act as competing RNA to regulate stability, localization and translation activity of mRNAs in recipient cells.

Twitter Demographics

The data shown below were collected from the profiles of 21 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Germany 2 <1%
France 1 <1%
Czechia 1 <1%
Canada 1 <1%
Sweden 1 <1%
Unknown 228 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 66 28%
Researcher 42 18%
Student > Master 30 13%
Student > Bachelor 23 10%
Student > Doctoral Student 17 7%
Other 27 11%
Unknown 34 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 79 33%
Biochemistry, Genetics and Molecular Biology 53 22%
Medicine and Dentistry 28 12%
Engineering 8 3%
Immunology and Microbiology 7 3%
Other 17 7%
Unknown 47 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2021.
All research outputs
#1,062,941
of 18,468,417 outputs
Outputs from Biology Direct
#45
of 600 outputs
Outputs of similar age
#10,161
of 168,323 outputs
Outputs of similar age from Biology Direct
#2
of 6 outputs
Altmetric has tracked 18,468,417 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 600 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,323 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.