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Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

Overview of attention for article published in Biology Direct, August 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

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4 X users
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65 patents

Citations

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231 Dimensions

Readers on

mendeley
377 Mendeley
citeulike
1 CiteULike
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Title
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
Published in
Biology Direct, August 2009
DOI 10.1186/1745-6150-4-29
Pubmed ID
Authors

Kira S Makarova, Yuri I Wolf, John van der Oost, Eugene V Koonin

Abstract

In eukaryotes, RNA interference (RNAi) is a major mechanism of defense against viruses and transposable elements as well of regulating translation of endogenous mRNAs. The RNAi systems recognize the target RNA molecules via small guide RNAs that are completely or partially complementary to a region of the target. Key components of the RNAi systems are proteins of the Argonaute-PIWI family some of which function as slicers, the nucleases that cleave the target RNA that is base-paired to a guide RNA. Numerous prokaryotes possess the CRISPR-associated system (CASS) of defense against phages and plasmids that is, in part, mechanistically analogous but not homologous to eukaryotic RNAi systems. Many prokaryotes also encode homologs of Argonaute-PIWI proteins but their functions remain unknown.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 377 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Germany 4 1%
Chile 1 <1%
France 1 <1%
Netherlands 1 <1%
Sweden 1 <1%
India 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Other 4 1%
Unknown 357 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 23%
Researcher 65 17%
Student > Master 48 13%
Student > Bachelor 44 12%
Student > Doctoral Student 17 5%
Other 46 12%
Unknown 69 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 156 41%
Biochemistry, Genetics and Molecular Biology 115 31%
Immunology and Microbiology 9 2%
Chemistry 3 <1%
Computer Science 3 <1%
Other 17 5%
Unknown 74 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#3,285,936
of 25,734,859 outputs
Outputs from Biology Direct
#127
of 538 outputs
Outputs of similar age
#11,400
of 105,577 outputs
Outputs of similar age from Biology Direct
#4
of 4 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,577 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.