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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis
|
|---|---|
| Published in |
AIDS Research and Therapy, January 2017
|
| DOI | 10.1186/s12981-016-0128-5 |
| Pubmed ID | |
| Authors |
Amrei von Braun, Christine Sekaggya-Wiltshire, Alexandra U. Scherrer, Brian Magambo, Andrew Kambugu, Jan Fehr, Barbara Castelnuovo |
| Abstract |
This cross-sectional study took place in the integrated tuberculosis (TB) clinic of a large outpatient clinic for HIV-infected patients in Kampala, Uganda. The purpose of this study was to describe the proportion of TB/HIV co-infected adults with virological failure, type and frequency of HIV drug resistance-associated mutations, and the proportion of patients with suboptimal efavirenz levels. HIV-1 plasma viral loads, CD4 cell count measurements, and efavirenz serum concentrations were done in TB/HIV co-infected adults. Genotypic resistance testing was performed in case of confirmed virological failure. After a median time on ART of 6 months, virological failure was found in 22/152 patients (14.5%). Of 147 participants with available efavirenz serum concentration, 26 (17.6%) had at least one value below the reference range, including 20/21 (95.2%) patients with confirmed virological failure. Genotypic resistance testing was available for 16/22 (72.7%) patients, of which 15 (93.8%) had at least one major mutation, most commonly M184V (81.2%) and K103NS (68.8%). We found a high proportion of TB/HIV co-infected patients with virological failure, the majority of which had developed relevant resistance-mutations after a median time on anti-retroviral treatment (ART) of 6 months. Virological monitoring should be prioritized in TB/HIV co-infected patients in resource-limited settings. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 25% |
| Researcher | 19 | 18% |
| Student > Ph. D. Student | 9 | 8% |
| Student > Bachelor | 6 | 6% |
| Lecturer | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 26 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 36% |
| Nursing and Health Professions | 11 | 10% |
| Immunology and Microbiology | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Other | 11 | 10% |
| Unknown | 30 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2017.
All research outputs
#15,431,277
of 22,940,083 outputs
Outputs from AIDS Research and Therapy
#355
of 554 outputs
Outputs of similar age
#256,771
of 421,054 outputs
Outputs of similar age from AIDS Research and Therapy
#9
of 10 outputs
Altmetric has tracked 22,940,083 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,054 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.