Title |
Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets
|
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Published in |
Lipids in Health and Disease, October 2005
|
DOI | 10.1186/1476-511x-4-23 |
Pubmed ID | |
Authors |
Knut A Eliassen, Bjørn P Brodal, Aud Svindland, Harald Osmundsen, Helle Rønning, Srdjan Djurovic, Kåre Berg |
Abstract |
In man, elevated levels of plasma plipoprotein (a) (Lp(a)) is a cardiovascular risk factor, and oxidized phospholipids are believed to play a role as modulators of inflammatory processes such as atherosclerosis. Polyamines are potent antioxidants and anti-inflammatory agents. It was therefore of interest to examine polyamines and their metabolism in LPA transgenic mice. Concentration of the polyamines putrescine, spermidine and spermine as well as the activity of peroxisomal polyamine oxidase and two other peroxisomal enzymes, acyl-CoA oxidase and catalase were measured. The mice were fed either a standard diet or a diet high in fat and cholesterol (HFHC). Some of the mice in each feeding group were in addition given aminoguanidine (AG), a specific inhibitor of diamine oxidase, which catalyses degradation of putrescine, and also inhibits non-enzymatic glycosylation of protein which is implicated in the aetiology of atherosclerosis in diabetic patients. Non-transgenic mice were used as controls. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 17% |
Professor > Associate Professor | 2 | 17% |
Student > Doctoral Student | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Professor | 1 | 8% |
Other | 2 | 17% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 4 | 33% |