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Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

Overview of attention for article published in BMC Biology, June 2013
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Title
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
Published in
BMC Biology, June 2013
DOI 10.1186/1741-7007-11-67
Pubmed ID
Authors

James I MacRae, Matthew WA Dixon, Megan K Dearnley, Hwa H Chua, Jennifer M Chambers, Shannon Kenny, Iveta Bottova, Leann Tilley, Malcolm J McConville

Abstract

The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be highly streamlined, with glycolysis providing most of the cellular ATP. However, these parasitic stages express all the enzymes needed for a canonical mitochondrial tricarboxylic acid (TCA) cycle, and it was recently proposed that they may catabolize glutamine via an atypical branched TCA cycle. Whether these stages catabolize glucose in the TCA cycle and what is the functional significance of mitochondrial metabolism remains unresolved.

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The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 2%
Portugal 2 <1%
Indonesia 1 <1%
France 1 <1%
India 1 <1%
Australia 1 <1%
China 1 <1%
United States 1 <1%
Unknown 255 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 86 32%
Researcher 52 19%
Student > Master 36 13%
Student > Bachelor 20 7%
Student > Postgraduate 17 6%
Other 29 11%
Unknown 28 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 94 35%
Biochemistry, Genetics and Molecular Biology 69 26%
Medicine and Dentistry 16 6%
Immunology and Microbiology 13 5%
Chemistry 13 5%
Other 24 9%
Unknown 39 15%