Title |
The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)
|
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Published in |
Respiratory Research, January 2017
|
DOI | 10.1186/s12931-017-0505-1 |
Pubmed ID | |
Authors |
Clara E. Green, Alice M. Turner |
Abstract |
COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its' progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 40% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 130 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 15% |
Researcher | 16 | 12% |
Student > Master | 15 | 12% |
Student > Bachelor | 12 | 9% |
Student > Doctoral Student | 8 | 6% |
Other | 19 | 15% |
Unknown | 41 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 28% |
Biochemistry, Genetics and Molecular Biology | 16 | 12% |
Agricultural and Biological Sciences | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Engineering | 5 | 4% |
Other | 12 | 9% |
Unknown | 45 | 35% |