Title |
Regulatory T cells in skin regeneration and wound healing
|
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Published in |
Military Medical Research, October 2023
|
DOI | 10.1186/s40779-023-00484-6 |
Pubmed ID | |
Authors |
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi |
Abstract |
As the body's integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. Such temporally- and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation. In this context, regulatory T cells (Tregs) hold a key role in balancing immune homeostasis and mediating cutaneous wound healing. A comprehensive understanding of Tregs' multifaceted field of activity may help decipher wound pathologies and, ultimately, establish new treatment modalities. Herein, we review the role of Tregs in orchestrating the regeneration of skin adnexa and catalyzing healthy wound repair. Further, we discuss how Tregs operate during fibrosis, keloidosis, and scarring. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 50% |
United States | 1 | 17% |
Germany | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 33% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 6 | 22% |
Student > Ph. D. Student | 4 | 15% |
Student > Master | 3 | 11% |
Researcher | 2 | 7% |
Lecturer | 1 | 4% |
Other | 2 | 7% |
Unknown | 9 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 7 | 26% |
Immunology and Microbiology | 3 | 11% |
Medicine and Dentistry | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Other | 2 | 7% |
Unknown | 8 | 30% |