Title |
Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
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Published in |
BMC Systems Biology, May 2011
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DOI | 10.1186/1752-0509-5-68 |
Pubmed ID | |
Authors |
Ian M Overton, Shirley Graham, Katherine A Gould, Jason Hinds, Catherine H Botting, Sally Shirran, Geoffrey J Barton, Peter J Coote |
Abstract |
Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important. Antimicrobial peptides represent a source of potential novel antibiotics to combat resistant bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). A promising antimicrobial peptide is ranalexin, which has potent activity against Gram-positive bacteria, and particularly S. aureus. Understanding mode of action is a key component of drug discovery and network biology approaches enable a global, integrated view of microbial physiology, including mechanisms of antibiotic killing. We developed a systems-wide functional association network approach to integrate proteome and transcriptome profiles, enabling study of drug resistance and mode of action. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 5% |
Belgium | 2 | 2% |
Portugal | 1 | <1% |
Canada | 1 | <1% |
Malaysia | 1 | <1% |
Denmark | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 99 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 28 | 25% |
Student > Ph. D. Student | 23 | 21% |
Student > Bachelor | 13 | 12% |
Student > Master | 11 | 10% |
Student > Doctoral Student | 6 | 5% |
Other | 20 | 18% |
Unknown | 10 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 45% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Medicine and Dentistry | 9 | 8% |
Immunology and Microbiology | 8 | 7% |
Computer Science | 4 | 4% |
Other | 11 | 10% |
Unknown | 13 | 12% |