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Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

Overview of attention for article published in Cardiovascular Diabetology, December 2016
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Title
Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis
Published in
Cardiovascular Diabetology, December 2016
DOI 10.1186/s12933-016-0481-7
Pubmed ID
Authors

Morgane Evin, Kathryn M. Broadhouse, Fraser M. Callaghan, Rachel T. McGrath, Sarah Glastras, Rebecca Kozor, Samantha L. Hocking, Jérôme Lamy, Alban Redheuil, Nadjia Kachenoura, Greg R. Fulcher, Gemma A. Figtree, Stuart M. Grieve

Abstract

Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function. Twenty patients with obesity and T2D (55 ± 8 years) and nineteen healthy controls (48 ± 13 years) were imaged using cine steady state free precession and 2-point Dixon cardiovascular magnetic resonance. LA function was quantified using a feature tracking technique with definition of phasic longitudinal strain and strain rates, as well as radial motion fraction and radial velocities. Systolic left ventricular size and function were similar between the obesity and type 2 diabetes and control groups by MRI. All patients except four had normal diastolic assessment by echocardiography. In contrast, measures of LA function using magnetic resonance feature tracking were uniformly altered in the obesity and type 2 diabetes group only. Although there was no significant difference in intra-myocardial fat fraction, Dixon 3D epicardial fat volume(EFV) was significantly elevated in the obesity and type 2 diabetes versus control group (135 ± 31 vs. 90 ± 30 mL/m(2), p < 0.001). There were significant correlations between LA functional indices and both BMI and EFV (p ≤ 0.007). LA MRI-strain may be a sensitive tool for the detection of early diastolic dysfunction in individuals with obesity and type 2 diabetes and correlated with BMI and epicardial fat supporting a possible association between adiposity and LA strain. Trials Registration Australian New Zealand Clinical Trials Registry No. ACTRN12613001069741.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 82 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 15%
Student > Postgraduate 8 10%
Student > Master 8 10%
Other 6 7%
Student > Bachelor 6 7%
Other 20 24%
Unknown 22 27%
Readers by discipline Count As %
Medicine and Dentistry 34 41%
Biochemistry, Genetics and Molecular Biology 3 4%
Engineering 3 4%
Unspecified 3 4%
Nursing and Health Professions 2 2%
Other 9 11%
Unknown 28 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
All research outputs
#15,431,277
of 22,940,083 outputs
Outputs from Cardiovascular Diabetology
#849
of 1,391 outputs
Outputs of similar age
#256,512
of 421,019 outputs
Outputs of similar age from Cardiovascular Diabetology
#16
of 18 outputs
Altmetric has tracked 22,940,083 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,391 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.