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Single-step synthesis of a new series of meso di-Mannich bases from the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo[8.8.1.1.8,170.2,7011,16]icosane and p-substituted phenols

Overview of attention for article published in BMC Chemistry, June 2013
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Title
Single-step synthesis of a new series of meso di-Mannich bases from the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo[8.8.1.1.8,170.2,7011,16]icosane and p-substituted phenols
Published in
BMC Chemistry, June 2013
DOI 10.1186/1752-153x-7-100
Pubmed ID
Authors

Augusto Rivera, Diego Quiroga, Jaime Ríos-Motta, Václav Eigner, Michal Dušek

Abstract

The results presented herein show that the cyclic aminal (2S,7R,11S,16R)-1,8,10,17-tetraazapentacyclo[8.8.1.1.(8,17)0.(2,7)0(11,16)]icosane (6), derived from cis-(meso)-1,2-diaminocyclohexane and formaldehyde, is a suitable substrate for the preption of a series of cis-meso Mannich bases such as 8a-l by reaction with p-substituted phenols 7a-l in basic media. These compounds are valuable synthetic products and may find application in asymmetric catalysis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 25%
Unspecified 1 8%
Other 1 8%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Other 2 17%
Unknown 3 25%
Readers by discipline Count As %
Chemistry 7 58%
Unspecified 1 8%
Immunology and Microbiology 1 8%
Neuroscience 1 8%
Unknown 2 17%