Title |
Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections
|
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Published in |
Neural Development, June 2013
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DOI | 10.1186/1749-8104-8-11 |
Pubmed ID | |
Authors |
Jianmin Su, Michael A Klemm, Anne M Josephson, Michael A Fox |
Abstract |
Retinal ganglion cells (RGCs), the output neurons of the retina, project to over 20 distinct brain nuclei, including the lateral geniculate nucleus (LGN), a thalamic region comprised of three functionally distinct subnuclei: the ventral LGN (vLGN), the dorsal LGN (dLGN) and the intergeniculate leaflet (IGL). We previously identified reelin, an extracellular glycoprotein, as a critical factor that directs class-specific targeting of these subnuclei. Reelin is known to bind to two receptors: very-low-density lipoprotein receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2). Here we examined the roles of these canonical reelin receptors in retinogeniculate targeting. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 22% |
Student > Bachelor | 5 | 16% |
Student > Master | 5 | 16% |
Researcher | 4 | 13% |
Professor | 3 | 9% |
Other | 6 | 19% |
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Psychology | 1 | 3% |
Other | 2 | 6% |
Unknown | 2 | 6% |