Title |
Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre
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Published in |
World Allergy Organization Journal, January 2017
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DOI | 10.1186/s40413-016-0135-y |
Pubmed ID | |
Authors |
Ru-Xin Foong, Rosan Meyer, Robert Dziubak, Adriana Chebar Lozinsky, Heather Godwin, Kate Reeve, Syeda Tahmida Hussain, Romman Nourzaie, Neil Shah |
Abstract |
There is no data on the prevalence of vitamin D deficiency in children with non-immunoglobulin-E (IgE) mediated gastrointestinal food allergy. The aims of our study were to understand the prevalence of vitamin D insufficiency and deficiency in children with non-IgE mediated gastrointestinal food allergy and identify predisposing factors. This was a retrospective study which looked at data from Great Ormond Street Hospital from January 2002 to September 2015. Children 0-18 years old with a confirmed diagnosis of non-IgE mediated gastrointestinal food allergy who had a vitamin D level measured during the course of their disease were included. Low vitamin D levels were defined as <50 nmol/L; insufficient levels were defined as 25-50 nmol/L and deficient levels as <25 nmol/L. Patient characteristics and clinical factors were also recorded. Ninety-two patients met the study criteria; 49% were female and median age was 10 years 2 months [IQR: 4 years 8 months to 13 years 7 months]. Of the cohort, 26% (24/92) had low vitamin D levels; 16% had insufficient vitamin D levels and 10% had vitamin D deficiency. Gender (p = 0.043) and age (p = 0.035) were significantly associated with low vitamin D levels. Twelve percent of children who were on an amino acid formula (AAF) had low vitamin D compared to 31% of children who were not (p = 0.06). No other clinical factors were found to be significantly associated with low vitamin D levels. Children with non-IgE mediated gastrointestinal food allergy are at risk of vitamin D insufficiency and deficiency. Further prospective studies need to be performed in all children with non-IgE mediated gastrointestinal food allergies. The study was registered with the GOSH Research & Development department as a retrospective case note review. The Health Research Authority confirmed that NHS Research and Ethics Committee approval was not required; thus there is no trial registration number. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 9 | 31% |
United States | 3 | 10% |
Spain | 1 | 3% |
Romania | 1 | 3% |
Canada | 1 | 3% |
Argentina | 1 | 3% |
Dominican Republic | 1 | 3% |
Unknown | 12 | 41% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 59% |
Practitioners (doctors, other healthcare professionals) | 9 | 31% |
Scientists | 3 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 14% |
Student > Master | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Doctoral Student | 3 | 9% |
Other | 3 | 9% |
Other | 5 | 14% |
Unknown | 11 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 37% |
Agricultural and Biological Sciences | 4 | 11% |
Nursing and Health Professions | 2 | 6% |
Environmental Science | 1 | 3% |
Decision Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 13 | 37% |