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COMT genetic variation confers risk for psychotic and affective disorders: a case control study

Overview of attention for article published in Behavioral and Brain Functions, October 2005
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Title
COMT genetic variation confers risk for psychotic and affective disorders: a case control study
Published in
Behavioral and Brain Functions, October 2005
DOI 10.1186/1744-9081-1-19
Pubmed ID
Abstract

Variation in the COMT gene has been implicated in a number of psychiatric disorders, including psychotic, affective and anxiety disorders. The majority of these studies have focused on the functional Val108/158Met polymorphism and yielded conflicting results, with limited studies examining the relationship between other polymorphisms, or haplotypes, and psychiatric illness. We hypothesized that COMT variation may confer a general risk for psychiatric disorders and have genotyped four COMT variants (Val158Met, rs737865, rs165599, and a SNP in the P2 promoter [-278A/G; rs2097603]) in 394 Caucasian cases and 467 controls. Cases included patients with schizophrenia (n = 196), schizoaffective disorder (n = 62), bipolar disorder (n = 82), major depression (n = 30), and patients diagnosed with either psychotic disorder NOS or depressive disorder NOS (n = 24).

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Canada 1 1%
Brazil 1 1%
Unknown 79 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 19%
Researcher 13 16%
Student > Bachelor 11 13%
Professor 9 11%
Professor > Associate Professor 8 10%
Other 20 24%
Unknown 6 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 24%
Psychology 15 18%
Medicine and Dentistry 15 18%
Neuroscience 8 10%
Biochemistry, Genetics and Molecular Biology 6 7%
Other 7 8%
Unknown 12 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.
All research outputs
#2,897,666
of 3,633,792 outputs
Outputs from Behavioral and Brain Functions
#173
of 253 outputs
Outputs of similar age
#67,679
of 85,306 outputs
Outputs of similar age from Behavioral and Brain Functions
#9
of 9 outputs
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