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COMT genetic variation confers risk for psychotic and affective disorders: a case control study

Overview of attention for article published in Behavioral and Brain Functions, October 2005
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Title
COMT genetic variation confers risk for psychotic and affective disorders: a case control study
Published in
Behavioral and Brain Functions, October 2005
DOI 10.1186/1744-9081-1-19
Pubmed ID
Authors

Birgit Funke, Anil K Malhotra, Christine T Finn, Alex M Plocik, Stephen L Lake, Todd Lencz, Pamela DeRosse, John M Kane, Raju Kucherlapati

Abstract

Variation in the COMT gene has been implicated in a number of psychiatric disorders, including psychotic, affective and anxiety disorders. The majority of these studies have focused on the functional Val108/158Met polymorphism and yielded conflicting results, with limited studies examining the relationship between other polymorphisms, or haplotypes, and psychiatric illness. We hypothesized that COMT variation may confer a general risk for psychiatric disorders and have genotyped four COMT variants (Val158Met, rs737865, rs165599, and a SNP in the P2 promoter [-278A/G; rs2097603]) in 394 Caucasian cases and 467 controls. Cases included patients with schizophrenia (n = 196), schizoaffective disorder (n = 62), bipolar disorder (n = 82), major depression (n = 30), and patients diagnosed with either psychotic disorder NOS or depressive disorder NOS (n = 24).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Canada 1 1%
Brazil 1 1%
Unknown 91 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 17%
Researcher 13 14%
Student > Bachelor 12 13%
Professor 8 8%
Professor > Associate Professor 8 8%
Other 24 25%
Unknown 14 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 22%
Medicine and Dentistry 17 18%
Psychology 15 16%
Neuroscience 8 8%
Biochemistry, Genetics and Molecular Biology 7 7%
Other 8 8%
Unknown 19 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.
All research outputs
#20,195,024
of 22,712,476 outputs
Outputs from Behavioral and Brain Functions
#333
of 391 outputs
Outputs of similar age
#57,004
of 58,898 outputs
Outputs of similar age from Behavioral and Brain Functions
#3
of 4 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 391 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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