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High frequency of the X-chromosome inactivation in young female patients with high-grade glioma

Overview of attention for article published in Diagnostic Pathology, June 2013
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1 X user
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1 Facebook page

Citations

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Title
High frequency of the X-chromosome inactivation in young female patients with high-grade glioma
Published in
Diagnostic Pathology, June 2013
DOI 10.1186/1746-1596-8-101
Pubmed ID
Authors

Gang Li, Zhiguo Zhang, Tianbo Jin, Hongjuan Liang, Yanyang Tu, Li Gong, Zhongping Chen, Guodong Gao

Abstract

Gliomas are common tumors and high-grade ones account for 62% of primary malignant brain tumors. Though current evidence have suggested that inherited risks play a role in glioma susceptibility, it was conveyed that glioma was such a complex disease, and the direct genetic contribution to glioma risk factors and its relation to other factors should be discussed more deeply. X-chromosome inactivation (XCI) is the mechanism by which gene dosage equivalence is achieved between female mammals with two X chromosomes and male mammals with a single X chromosome. As skewed XCI has been linked to development of some solid tumors, including ovarian, breast, and pulmonary and esophageal carcinomas, it is challenging to elucidate the relation of skewed XCI to high-grade gliomas development.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 18%
Researcher 6 15%
Student > Ph. D. Student 6 15%
Other 5 13%
Student > Bachelor 4 10%
Other 6 15%
Unknown 5 13%
Readers by discipline Count As %
Medicine and Dentistry 12 31%
Agricultural and Biological Sciences 8 21%
Biochemistry, Genetics and Molecular Biology 5 13%
Immunology and Microbiology 2 5%
Neuroscience 2 5%
Other 5 13%
Unknown 5 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.
All research outputs
#17,690,153
of 22,712,476 outputs
Outputs from Diagnostic Pathology
#671
of 1,120 outputs
Outputs of similar age
#141,409
of 196,823 outputs
Outputs of similar age from Diagnostic Pathology
#10
of 24 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,120 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,823 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.