Title |
High frequency of the X-chromosome inactivation in young female patients with high-grade glioma
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Published in |
Diagnostic Pathology, June 2013
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DOI | 10.1186/1746-1596-8-101 |
Pubmed ID | |
Authors |
Gang Li, Zhiguo Zhang, Tianbo Jin, Hongjuan Liang, Yanyang Tu, Li Gong, Zhongping Chen, Guodong Gao |
Abstract |
Gliomas are common tumors and high-grade ones account for 62% of primary malignant brain tumors. Though current evidence have suggested that inherited risks play a role in glioma susceptibility, it was conveyed that glioma was such a complex disease, and the direct genetic contribution to glioma risk factors and its relation to other factors should be discussed more deeply. X-chromosome inactivation (XCI) is the mechanism by which gene dosage equivalence is achieved between female mammals with two X chromosomes and male mammals with a single X chromosome. As skewed XCI has been linked to development of some solid tumors, including ovarian, breast, and pulmonary and esophageal carcinomas, it is challenging to elucidate the relation of skewed XCI to high-grade gliomas development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 18% |
Researcher | 6 | 15% |
Student > Ph. D. Student | 6 | 15% |
Other | 5 | 13% |
Student > Bachelor | 4 | 10% |
Other | 6 | 15% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 31% |
Agricultural and Biological Sciences | 8 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Immunology and Microbiology | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 5 | 13% |
Unknown | 5 | 13% |