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DNA methyltransferases and their roles in tumorigenesis

Overview of attention for article published in Biomarker Research, January 2017
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Mentioned by

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2 tweeters

Citations

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196 Dimensions

Readers on

mendeley
269 Mendeley
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Title
DNA methyltransferases and their roles in tumorigenesis
Published in
Biomarker Research, January 2017
DOI 10.1186/s40364-017-0081-z
Pubmed ID
Authors

Wu Zhang, Jie Xu

Abstract

DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus indicating that epigenetic disruptions caused by DNMT abnormalities are associated with tumorigenesis. Herein, we review the latest findings related to DNMT alterations in cancer cells and discuss the contributions of these effects to oncogenic phenotypes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 269 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 269 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 20%
Student > Master 42 16%
Student > Bachelor 40 15%
Researcher 25 9%
Student > Doctoral Student 14 5%
Other 28 10%
Unknown 65 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 87 32%
Agricultural and Biological Sciences 27 10%
Medicine and Dentistry 25 9%
Chemistry 12 4%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Other 34 13%
Unknown 76 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2017.
All research outputs
#15,437,553
of 22,947,506 outputs
Outputs from Biomarker Research
#161
of 317 outputs
Outputs of similar age
#254,640
of 417,402 outputs
Outputs of similar age from Biomarker Research
#6
of 7 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 317 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,402 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.