Title |
Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
|
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Published in |
BMC Genomics, June 2013
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DOI | 10.1186/1471-2164-14-404 |
Pubmed ID | |
Authors |
Sarbashis Das, Tanmoy Roychowdhury, Parameet Kumar, Anil Kumar, Priya Kalra, Jitendra Singh, Sarman Singh, HK Prasad, Alok Bhattacharya |
Abstract |
Tuberculosis remains a major public health problem. Clinical tuberculosis manifests often as pulmonary and occasionally as extra-pulmonary tuberculosis. The emergence of drug resistant tubercle bacilli and its association with HIV is a formidable challenge to curb the spread of tuberculosis. There have been concerted efforts by whole genome sequencing and bioinformatics analysis to identify genomic patterns and to establish a relationship between the genotype of the organism and clinical manifestation of tuberculosis. Extra-pulmonary TB constitutes 15-20 percent of the total clinical cases of tuberculosis reported among immunocompetent patients, whereas among HIV patients the incidence is more than 50 percent. Genomic analysis of M. tuberculosis isolates from extra pulmonary patients has not been explored. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 1% |
United States | 1 | 1% |
Nigeria | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 74 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 23% |
Researcher | 18 | 23% |
Student > Master | 10 | 13% |
Professor | 5 | 6% |
Student > Bachelor | 4 | 5% |
Other | 12 | 15% |
Unknown | 11 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 29% |
Medicine and Dentistry | 23 | 29% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Mathematics | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 5 | 6% |
Unknown | 14 | 18% |