Title |
Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals
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Published in |
Immunity & Ageing, January 2017
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DOI | 10.1186/s12979-017-0084-5 |
Pubmed ID | |
Authors |
Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira, Ana Maria Caetano Faria, Olindo Assis Martins-Filho |
Abstract |
Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian individuals was studied. We analysed frequencies of cytokine-producing lymphocytes and innate immune cells from individuals at several ages spanning a lifetime period (0-85 years). Healthy adult individuals presented a balanced profile suggestive of a mature immune system with equal contributions of both innate and adaptive immunity and of both categories of cytokines (inflammatory and regulatory). In healthy newborns and elderly, innate immune cells, especially neutrophils and NK-cells, contributed the most to a balanced profile of cytokines. Our results support the hypothesis that ageing is not associated with a progressive pro-inflammatory cytokine production by all leukocytes but rather with distinct fluctuations in the frequency of cytokine-producing cells throughout life. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 33% |
Belgium | 1 | 17% |
Iran, Islamic Republic of | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Scientists | 1 | 17% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 19% |
Student > Master | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Professor | 3 | 6% |
Researcher | 3 | 6% |
Other | 7 | 13% |
Unknown | 17 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 10 | 19% |
Medicine and Dentistry | 5 | 10% |
Nursing and Health Professions | 5 | 10% |
Agricultural and Biological Sciences | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Other | 7 | 13% |
Unknown | 17 | 33% |