Title |
Fetal brain genomic reprogramming following asphyctic preconditioning
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Published in |
BMC Neuroscience, June 2013
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DOI | 10.1186/1471-2202-14-61 |
Pubmed ID | |
Authors |
Kimberly EM Cox-Limpens, Johan SH Vles, Jana Schlechter, Luc JI Zimmermann, Eveline Strackx, Antonio WD Gavilanes |
Abstract |
Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of preconditioning. Therefore we investigated whole genome differential gene expression in the preconditioned rat brain. FA preconditioning was induced on embryonic day 17 by reversibly clamping uterine circulation. Male control and FA offspring were sacrificed 96 h after FA preconditioning. Whole genome transcription was investigated with Affymetrix Gene1.0ST chip. |
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 25% |
Student > Ph. D. Student | 4 | 20% |
Student > Master | 4 | 20% |
Other | 3 | 15% |
Student > Bachelor | 1 | 5% |
Other | 2 | 10% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 20% |
Psychology | 4 | 20% |
Neuroscience | 3 | 15% |
Medicine and Dentistry | 3 | 15% |
Computer Science | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |