Title |
The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms
|
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Published in |
Nutrition Journal, June 2013
|
DOI | 10.1186/1475-2891-12-89 |
Pubmed ID | |
Authors |
Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn |
Abstract |
The prevalence rates of overweight and obesity are considered an important public issue in the United States, and both of these conditions are increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Vitamin D deficiency is highly prevalent in patients with obesity, and many studies have demonstrated the significant effect of calcitriol on adipocytes. Genetic studies have provided an opportunity to determine which proteins link vitamin D to obesity pathology, including the vitamin D receptor, toll-like receptors, the renin-angiotensin system, apolipoprotein E, vascular endothelial growth factor, and poly (ADP-ribose) polymerase-1. Vitamin D also exerts its effect on obesity through cell-signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the reduced form of nicotinamide adenine dinucleotide phosphate, prostaglandins, reactive oxygen species, and nitric oxide synthase.In conclusion, vitamin D may have a role in obesity. The best form of vitamin D for use in the obese individuals is calcitriol because it is the active form of the vitamin D₃ metabolite, its receptors are present in adipocytes, and modulates inflammatory cytokine expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 19% |
United States | 4 | 19% |
Australia | 2 | 10% |
Spain | 2 | 10% |
Finland | 1 | 5% |
Brunei Darussalam | 1 | 5% |
South Africa | 1 | 5% |
Germany | 1 | 5% |
Saudi Arabia | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 14% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 15 | 71% |
Practitioners (doctors, other healthcare professionals) | 4 | 19% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Scientists | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Netherlands | 1 | <1% |
India | 1 | <1% |
Mexico | 1 | <1% |
Nigeria | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 170 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 30 | 17% |
Student > Bachelor | 27 | 15% |
Researcher | 19 | 11% |
Student > Postgraduate | 14 | 8% |
Other | 13 | 7% |
Other | 30 | 17% |
Unknown | 44 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 33% |
Agricultural and Biological Sciences | 34 | 19% |
Nursing and Health Professions | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Sports and Recreations | 3 | 2% |
Other | 13 | 7% |
Unknown | 49 | 28% |