Title |
Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial
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Published in |
BMC Psychiatry, June 2013
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DOI | 10.1186/1471-244x-13-176 |
Pubmed ID | |
Authors |
Cenk Tek, Sinan Guloksuz, Vinod H Srihari, Erin L Reutenauer |
Abstract |
Obesity is a growing health problem leading to high rates of mortality and morbidity in patients with severe mental illness (SMI). The increased rate of obesity is largely attributed to antipsychotic use. The effect of antipsychotic medications on H1 and 5HT2 receptors has been associated with weight gain, but there is also a substantial amount of evidence showing that D2 receptor blockade may be responsible for weight gain by interacting with the dopamine-opioid system. Unfortunately, current available medications for weight loss have limited efficacy in this population. Naltrexone, an opioid receptor antagonist, may be a promising agent to reduce antipsychotic induced weight gain by decreasing food cravings. We aim to investigate the safety and efficacy of two doses of naltrexone (25 mg & 50 mg) versus placebo for weight and health risk reduction in overweight and obese individuals (BMI ≥ 28) with SMI, who gained weight while being treated with antipsychotics. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 318 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 48 | 15% |
Student > Master | 45 | 14% |
Student > Ph. D. Student | 41 | 13% |
Researcher | 33 | 10% |
Student > Doctoral Student | 21 | 7% |
Other | 56 | 17% |
Unknown | 79 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 72 | 22% |
Psychology | 42 | 13% |
Nursing and Health Professions | 31 | 10% |
Sports and Recreations | 15 | 5% |
Biochemistry, Genetics and Molecular Biology | 12 | 4% |
Other | 57 | 18% |
Unknown | 94 | 29% |