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High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study

Overview of attention for article published in Behavioral and Brain Functions, November 2008
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Title
High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study
Published in
Behavioral and Brain Functions, November 2008
DOI 10.1186/1744-9081-4-52
Pubmed ID
Authors

Osman Virit, Salih Selek, Mahmut Bulut, Haluk Asuman Savas, Hakim Celik, Ozcan Erel, Hasan Herken

Abstract

Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia. 26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured. The mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 +/- 26.53, 424.43 +/- 31.50 and 222.35 +/- 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group. Although the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Poland 1 3%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Bachelor 5 13%
Other 4 10%
Student > Master 4 10%
Student > Ph. D. Student 3 8%
Other 12 30%
Unknown 5 13%
Readers by discipline Count As %
Medicine and Dentistry 17 43%
Agricultural and Biological Sciences 6 15%
Biochemistry, Genetics and Molecular Biology 4 10%
Neuroscience 4 10%
Computer Science 1 3%
Other 2 5%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2022.
All research outputs
#14,829,726
of 25,249,294 outputs
Outputs from Behavioral and Brain Functions
#193
of 416 outputs
Outputs of similar age
#149,009
of 180,543 outputs
Outputs of similar age from Behavioral and Brain Functions
#10
of 16 outputs
Altmetric has tracked 25,249,294 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 416 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,543 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.