Title |
Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis
|
---|---|
Published in |
BMC Genomic Data, April 2013
|
DOI | 10.1186/1471-2156-14-30 |
Pubmed ID | |
Authors |
Wilfred Wu, Erin A S Clark, Gregory J Stoddard, W Scott Watkins, M Sean Esplin, Tracy A Manuck, Jinchuan Xing, Michael W Varner, Lynn B Jorde |
Abstract |
Because of the role of inflammation in preterm birth (PTB), polymorphisms in and near the interleukin-6 gene (IL6) have been association study targets. Several previous studies have assessed the association between PTB and a single nucleotide polymorphism (SNP), rs1800795, located in the IL6 gene promoter region. Their results have been inconsistent and SNP frequencies have varied strikingly among different populations. We therefore conducted a meta-analysis with subgroup analysis by population strata to: (1) reduce the confounding effect of population structure, (2) increase sample size and statistical power, and (3) elucidate the association between rs1800975 and PTB. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Uruguay | 2 | 5% |
United States | 1 | 2% |
Unknown | 38 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 27% |
Student > Master | 6 | 15% |
Student > Bachelor | 4 | 10% |
Researcher | 3 | 7% |
Professor > Associate Professor | 3 | 7% |
Other | 5 | 12% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 37% |
Agricultural and Biological Sciences | 9 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 5% |
Unknown | 9 | 22% |