Title |
Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection
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Published in |
Microbiome, June 2013
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DOI | 10.1186/2049-2618-1-18 |
Pubmed ID | |
Authors |
Caroline Vincent, David A Stephens, Vivian G Loo, Thaddeus J Edens, Marcel A Behr, Ken Dewar, Amee R Manges |
Abstract |
Antimicrobial use is thought to suppress the intestinal microbiota, thereby impairing colonization resistance and allowing Clostridium difficile to infect the gut. Additional risk factors such as proton-pump inhibitors may also alter the intestinal microbiota and predispose patients to Clostridium difficile infection (CDI). This comparative metagenomic study investigates the relationship between epidemiologic exposures, intestinal bacterial populations and subsequent development of CDI in hospitalized patients. We performed a nested case-control study including 25 CDI cases and 25 matched controls. Fecal specimens collected prior to disease onset were evaluated by 16S rRNA gene amplification and pyrosequencing to determine the composition of the intestinal microbiota during the at-risk period. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Ireland | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 140 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 22% |
Student > Ph. D. Student | 28 | 19% |
Student > Master | 19 | 13% |
Student > Bachelor | 12 | 8% |
Other | 8 | 5% |
Other | 19 | 13% |
Unknown | 29 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 40 | 27% |
Medicine and Dentistry | 27 | 18% |
Immunology and Microbiology | 16 | 11% |
Biochemistry, Genetics and Molecular Biology | 15 | 10% |
Environmental Science | 4 | 3% |
Other | 12 | 8% |
Unknown | 33 | 22% |