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Normal and cancer stem cells of the human female reproductive system

Overview of attention for article published in Reproductive Biology and Endocrinology, June 2013
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2 tweeters

Citations

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33 Dimensions

Readers on

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69 Mendeley
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Title
Normal and cancer stem cells of the human female reproductive system
Published in
Reproductive Biology and Endocrinology, June 2013
DOI 10.1186/1477-7827-11-53
Pubmed ID
Authors

Jacqueline López, Francisco J Valdez-Morales, Luis Benítez-Bribiesca, Marco Cerbón, Alejandro García Carrancá

Abstract

The female reproductive system (FRS) has a great capacity for regeneration. The existence of somatic stem cells (SSC) that are likely to reside in distinct tissue compartments of the FRS is anticipated. Normal SSC are capable of regenerating themselves, produce a progeny of cells that differentiate and maintain tissue architecture and functional characteristics, and respond to homeostatic controls. Among those SSC of the FRS that have been identified are: a) undifferentiated cells capable of differentiating into thecal cells and synthesizing hormones upon transplantation, b) ovarian surface epithelium stem cells, mitotically responsive to ovulation, c) uterine endometrial and myometrial cells, as clonogenic epithelial and stromal cells, and d) epithelial and mesenchymal cells with self-renewal capacity and multipotential from cervical tissues. Importantly, these cells are believed to significantly contribute to the development of different pathologies and tumors of the FRS.It is now widely accepted that cancer stem cells (CSC) are at the origin of many tumors. They are capable of regenerating themselves, produce a progeny that will differentiate aberrantly and do not respond adequately to homeostatic controls. Several cell surface antigens such as CD44, CD117, CD133 and MYD88 have been used to isolate ovarian cancer stem cells. Clonogenic epithelial and stromal endometrial and myometrial cells have been found in normal and cancer tissues, as side population, label-retaining cells, and CD146/PDGF-R beta-positive cells with stem-like features. In summary, here we describe a number of studies supporting the existence of somatic stem cells in the normal tissues and cancer stem cells in tumors of the human female reproductive system.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Colombia 1 1%
Germany 1 1%
Brazil 1 1%
Sweden 1 1%
United Kingdom 1 1%
Russia 1 1%
Unknown 62 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Researcher 9 13%
Student > Master 8 12%
Student > Bachelor 7 10%
Professor > Associate Professor 6 9%
Other 16 23%
Unknown 10 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 38%
Medicine and Dentistry 21 30%
Biochemistry, Genetics and Molecular Biology 7 10%
Computer Science 1 1%
Psychology 1 1%
Other 2 3%
Unknown 11 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2013.
All research outputs
#2,935,993
of 4,507,144 outputs
Outputs from Reproductive Biology and Endocrinology
#190
of 282 outputs
Outputs of similar age
#59,130
of 89,506 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#12
of 15 outputs
Altmetric has tracked 4,507,144 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 282 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,506 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.