Title |
Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein
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Published in |
Virology Journal, March 2013
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DOI | 10.1186/1743-422x-10-79 |
Pubmed ID | |
Authors |
Anita Szalmás, Eszter Gyöngyösi, Annamária Ferenczi, Brigitta László, Tamás Karosi, Péter Csomor, Lajos Gergely, György Veress, József Kónya |
Abstract |
The Src family tyrosine kinases (SFK) are cellular regulatory proteins that influence cell adhesion, proliferation, invasion and survival during tumor development. Elevated activity of Src was associated with increased cell proliferation and invasivity in human papillomavirus (HPV)-associated malignancies; therefore, transduced human foreskin keratinocytes (HFK) were used to investigate whether SFK activation is a downstream effect of papillomaviral oncoproteins. Activation of ubiquitously expressed SFKs, namely Src, Yes and Fyn, was investigated in both proliferating and differentiating keratinocytes. |
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