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Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy

Overview of attention for article published in BMC Neurology, July 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent
facebook
2 Facebook pages

Citations

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11 Dimensions

Readers on

mendeley
33 Mendeley
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Title
Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy
Published in
BMC Neurology, July 2013
DOI 10.1186/1471-2377-13-70
Pubmed ID
Authors

Vered Raz, Ellen Sterrenburg, Samantha Routledge, Andrea Venema, Barbara M van der Sluijs, Capucine Trollet, George Dickson, Baziel GM van Engelen, Silvère M van der Maarel, Michael N Antoniou

Abstract

Muscle fibrosis characterizes degenerated muscles in muscular dystrophies and in late onset myopathies. Fibrotic muscles often exhibit thickening of the extracellular matrix (ECM). The molecular regulation of this process is not fully understood. In oculopharyngeal muscular dystrophy (OPMD), an expansion of an alanine tract at the N-terminus of poly(A)-binding protein nuclear 1 (PABPN1) causes muscle symptoms. OPMD patient muscle degeneration initiates after midlife, while at an earlier age carriers of alanine expansion mutant PABPN1 (expPABPN1) are clinically pre-symptomatic. OPMD is characterized by fibrosis in skeletal muscles but the causative molecular mechanisms are not fully understood.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Student > Bachelor 5 15%
Student > Master 4 12%
Researcher 4 12%
Librarian 2 6%
Other 5 15%
Unknown 6 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 27%
Agricultural and Biological Sciences 5 15%
Medicine and Dentistry 5 15%
Neuroscience 2 6%
Arts and Humanities 1 3%
Other 3 9%
Unknown 8 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2019.
All research outputs
#4,668,652
of 17,367,552 outputs
Outputs from BMC Neurology
#514
of 1,910 outputs
Outputs of similar age
#41,505
of 163,685 outputs
Outputs of similar age from BMC Neurology
#1
of 1 outputs
Altmetric has tracked 17,367,552 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,910 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them