Title |
Bone augmentation for cancellous bone-development of a new animal model
|
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Published in |
BMC Musculoskeletal Disorders, July 2013
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DOI | 10.1186/1471-2474-14-200 |
Pubmed ID | |
Authors |
Karina Klein, Enrico Zamparo, Peter W Kronen, Katharina Kämpf, Mariano Makara, Thomas Steffen, Brigitte von Rechenberg |
Abstract |
Reproducible and suitable animal models are required for in vivo experiments to investigate new biodegradable and osteoinductive biomaterials for augmentation of bones at risk for osteoporotic fractures. Sheep have especially been used as a model for the human spine due to their size and similar bone metabolism. However, although sheep and human vertebral bodies have similar biomechanical characteristics, the shape of the vertebral bodies, the size of the transverse processes, and the different orientation of the facet joints of sheep are quite different from those of humans making the surgical approach complicated and unpredictable. Therefore, an adequate and safe animal model for bone augmentation was developed using a standardized femoral and tibia augmentation site in sheep. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 6 | 21% |
Student > Master | 4 | 14% |
Student > Bachelor | 3 | 11% |
Student > Postgraduate | 3 | 11% |
Student > Ph. D. Student | 3 | 11% |
Other | 7 | 25% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 46% |
Veterinary Science and Veterinary Medicine | 3 | 11% |
Engineering | 3 | 11% |
Agricultural and Biological Sciences | 2 | 7% |
Environmental Science | 1 | 4% |
Other | 3 | 11% |
Unknown | 3 | 11% |