Title |
Safety, effectiveness, and cost of dipeptidyl peptidase-4 inhibitors versus intermediate acting insulin for type 2 diabetes: protocol for a systematic review and network meta-analysis
|
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Published in |
Systematic Reviews, June 2013
|
DOI | 10.1186/2046-4053-2-47 |
Pubmed ID | |
Authors |
Andrea C Tricco, Jesmin Antony, Charlene Soobiah, Brenda Hemmelgarn, David Moher, Brian Hutton, Catherine H Yu, Sumit R Majumdar, Sharon E Straus |
Abstract |
Type 2 diabetes mellitus (T2DM) results from insulin resistance and relative insulin deficiency. T2DM treatment is a step-wise approach beginning with lifestyle modifications (for example, diet, exercise), followed by the addition of oral hypoglycemic agents (for example, metformin). Patients who do not respond to first-line therapy are offered second-line therapy (for example, sulfonylureas). Third-line therapy may include insulin and/or dipeptidyl peptidase-4 (DPP-4) inhibitors.It is unclear whether DPP-4 inhibitors are safer and more effective than intermediate acting insulin for third-line management of T2DM. As such, our objective is to evaluate the comparative effectiveness, safety and cost-effectiveness of DPP-4 inhibitors versus intermediate acting insulin for T2DM patients who have failed both first- and second-line diabetes treatments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | <1% |
Ecuador | 1 | <1% |
Unknown | 117 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 22 | 18% |
Student > Bachelor | 19 | 16% |
Researcher | 17 | 14% |
Student > Ph. D. Student | 12 | 10% |
Other | 7 | 6% |
Other | 23 | 19% |
Unknown | 19 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 35 | 29% |
Nursing and Health Professions | 11 | 9% |
Economics, Econometrics and Finance | 9 | 8% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
Other | 23 | 19% |
Unknown | 25 | 21% |