Title |
Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses
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Published in |
Systematic Reviews, June 2013
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DOI | 10.1186/2046-4053-2-44 |
Pubmed ID | |
Authors |
Brian Hutton, Jennifer Tetzlaff, Fatemeh Yazdi, Justin Thielman, Salmaan Kanji, Dean Fergusson, Lise Bjerre, Edward Mills, Kristian Thorlund, Andrea Tricco, Sharon Straus, David Moher, Frans HH Leenen |
Abstract |
Hypertension has been cited as the most common attributable risk factor for death worldwide, and in Canada more than one of every five adults had this diagnosis in 2007. In addition to different lifestyle modifications, such as diet and exercise, there exist many pharmaco-therapies from different drug classes which can be used to lower blood pressure, thereby reducing the risk of serious clinical outcomes. In moderate and severe cases, more than one agent may be used. The optimal mono- and combination therapies for mild hypertension and moderate/severe hypertension are unclear, and clinical guidelines provide different recommendations for first line therapy. The objective of this review is to explore the relative benefits and safety of different pharmacotherapies for management of non-diabetic patients with hypertension, whether of a mild or moderate to severe nature. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 137 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 15% |
Student > Master | 16 | 12% |
Student > Bachelor | 13 | 9% |
Student > Doctoral Student | 11 | 8% |
Student > Ph. D. Student | 10 | 7% |
Other | 34 | 25% |
Unknown | 33 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 28% |
Nursing and Health Professions | 20 | 15% |
Psychology | 16 | 12% |
Unspecified | 4 | 3% |
Biochemistry, Genetics and Molecular Biology | 3 | 2% |
Other | 18 | 13% |
Unknown | 37 | 27% |