↓ Skip to main content

Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging

Overview of attention for article published in Clinical Epigenetics, February 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
twitter
5 X users
patent
1 patent

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
70 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Individual CpG sites that are associated with age and life expectancy become hypomethylated upon aging
Published in
Clinical Epigenetics, February 2017
DOI 10.1186/s13148-017-0315-9
Pubmed ID
Authors

Yan Zhang, Jan Hapala, Hermann Brenner, Wolfgang Wagner

Abstract

There is a growing interest in simple molecular biomarkers for biological aging. Age-associated DNA methylation (DNAm) changes at specific CG dinucleotides can be combined into epigenetic age predictors to estimate chronological age-and the deviation of chronological and predicted age (∆age) seems to be associated with all-cause mortality. In this study, we have further validated this association and analyzed whether or not individual age-associated CG-dinucleotides (CpGs) are related to life expectancy. In the German ESTHER cohort, we used 864 DNAm profiles of blood samples as the discovery set and 1000 DNAm profiles as the validation set to predict chronological age with three previously reported age predictors-based on 99, 71, or 353 age-associated CpGs. Several of these individual CpGs were significantly associated with life expectancy, and for some of these CpGs, this was even reproducible in the independent datasets. Notably, those CpGs that revealed significant association with life expectancy were overall rather hypomethylated upon aging. Individual age-associated CpGs may provide biomarkers for all-cause mortality-but confounding factors need to be critically taken into consideration, and alternative methods, which facilitate more quantitative measurements at individual CpGs, might be advantageous. Our data suggest that particularly specific CpGs that become hypomethylated upon aging are indicative of biological aging.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 26%
Student > Ph. D. Student 12 17%
Student > Master 10 14%
Student > Bachelor 8 11%
Student > Doctoral Student 6 9%
Other 6 9%
Unknown 10 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 34%
Agricultural and Biological Sciences 13 19%
Medicine and Dentistry 7 10%
Engineering 2 3%
Psychology 2 3%
Other 9 13%
Unknown 13 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2023.
All research outputs
#2,431,198
of 25,010,497 outputs
Outputs from Clinical Epigenetics
#154
of 1,421 outputs
Outputs of similar age
#49,524
of 430,664 outputs
Outputs of similar age from Clinical Epigenetics
#3
of 21 outputs
Altmetric has tracked 25,010,497 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,421 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,664 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.