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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity
|
|---|---|
| Published in |
Cancer & Metabolism, February 2017
|
| DOI | 10.1186/s40170-017-0165-0 |
| Pubmed ID | |
| Authors |
Renaud Vatrinet, Giulia Leone, Monica De Luise, Giulia Girolimetti, Michele Vidone, Giuseppe Gasparre, Anna Maria Porcelli |
| Abstract |
Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents a major modulator of electron transport chain activity and tricarboxylic acid cycle (TCA) flux, and is a pivotal enzyme in the metabolic reprogramming following a cancer cell's change in bioenergetic requirements. By contributing to the control of α-ketoglutarate levels, dynamics, and oxidation state, the α-ketoglutarate dehydrogenase is also essential in modulating the epigenetic landscape of cancer cells. In this review, we will discuss the manifold roles that this TCA enzyme and its substrate play in cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 125 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 23% |
| Researcher | 18 | 14% |
| Student > Master | 17 | 13% |
| Student > Bachelor | 11 | 9% |
| Professor > Associate Professor | 8 | 6% |
| Other | 21 | 17% |
| Unknown | 22 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 36% |
| Agricultural and Biological Sciences | 20 | 16% |
| Medicine and Dentistry | 11 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Immunology and Microbiology | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 26 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.
All research outputs
#18,925,846
of 23,454,152 outputs
Outputs from Cancer & Metabolism
#171
of 209 outputs
Outputs of similar age
#313,184
of 422,615 outputs
Outputs of similar age from Cancer & Metabolism
#4
of 4 outputs
Altmetric has tracked 23,454,152 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 209 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,615 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.