Title |
Differential response of BDCA-1+ and BDCA-3+myeloid dendritic cells to respiratory syncytial virus infection
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Published in |
Respiratory Research, July 2013
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DOI | 10.1186/1465-9921-14-71 |
Pubmed ID | |
Authors |
Meera R Gupta, Deepthi Kolli, Roberto P Garofalo |
Abstract |
Respiratory syncytial virus (RSV) is the leading cause of respiratory infections in children, elderly, and immunocompromised individuals. Severe infection is associated with short- and long-term morbidity including pneumonia, recurrent wheezing, and abnormal pulmonary function, and several lines of evidence indicate that impaired adaptive immune responses during infection are critical in the pathophysiology of RSV-mediated disease. Myeloid Dendritic cells (mDCs) play a pivotal role in shaping antiviral immune responses in the respiratory tract; however, few studies have examined the interactions between RSV and individual mDC subsets. In this study, we examined the effect of RSV on the functional response of primary mDC subsets (BDCA-1(+) and BDCA-3(+)) isolated from peripheral blood. |
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