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Mendeley readers
| Title |
Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis
|
|---|---|
| Published in |
Parasites & Vectors, March 2012
|
| DOI | 10.1186/1756-3305-5-53 |
| Pubmed ID | |
| Authors |
Francesca Tamarozzi, Nicholas Tendongfor, Peter A Enyong, Mathias Esum, Brian Faragher, Samuel Wanji, Mark J Taylor |
| Abstract |
Anti-Wolbachia treatment with doxycycline is effective in sterilising and killing adult Onchocerca volvulus nematodes, proving superior to ivermectin and of great potential as an alternative approach for the treatment and control of onchocerciasis, particularly in areas of Loa loa co-endemicity. Nevertheless, the length of the required treatment poses potential logistical problems and risk of poor compliance, raising a barrier to the use of doxycycline in Mass Drug Administration (MDA) strategies. In 2007 and 2008 a feasibility trial of community-directed treatment with doxycycline was carried out in two health districts in Cameroon, co-endemic for O. volvulus and L. loa. With 17,519 eligible subjects, the therapeutic coverage was 73.8% with 97.5% compliance, encouraging the feasibility of using doxycycline community-directed delivery in restricted populations of this size. The current study evaluated the effectiveness of this community-directed delivery of doxycycline four years after delivery. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| Unknown | 88 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 22% |
| Researcher | 17 | 19% |
| Student > Master | 12 | 13% |
| Other | 6 | 7% |
| Student > Bachelor | 5 | 6% |
| Other | 17 | 19% |
| Unknown | 13 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 26% |
| Agricultural and Biological Sciences | 17 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Immunology and Microbiology | 5 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 22 | 24% |
| Unknown | 13 | 14% |