Title |
Rule-based multi-scale simulation for drug effect pathway analysis
|
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Published in |
BMC Medical Informatics and Decision Making, April 2013
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DOI | 10.1186/1472-6947-13-s1-s4 |
Pubmed ID | |
Authors |
Woochang Hwang, Yongdeuk Hwang, Sunjae Lee, Doheon Lee |
Abstract |
Biological systems are robust and complex to maintain stable phenotypes under various conditions. In these systems, drugs reported the limited efficacy and unexpected side-effects. To remedy this situation, many pharmaceutical laboratories have begun to research combination drugs and some of them have shown successful clinical results. Complementary action of multiple compounds could increase efficacy as well as reduce side-effects through pharmacological interactions. However, experimental approach requires vast cost of preclinical experiments and tests as the number of possible combinations of compound dosages increases exponentially. Computer model-based experiments have been emerging as one of the most promising solutions to cope with such complexity. Though there have been many efforts to model specific molecular pathways using qualitative and quantitative formalisms, they suffer from unexpected results caused by distant interactions beyond their localized models. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 28% |
Student > Ph. D. Student | 9 | 23% |
Student > Doctoral Student | 6 | 15% |
Unspecified | 2 | 5% |
Student > Postgraduate | 2 | 5% |
Other | 4 | 10% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Computer Science | 5 | 13% |
Engineering | 4 | 10% |
Agricultural and Biological Sciences | 3 | 8% |
Other | 8 | 21% |
Unknown | 6 | 15% |