Title |
Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study
|
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Published in |
BMC Neurology, July 2013
|
DOI | 10.1186/1471-2377-13-76 |
Pubmed ID | |
Authors |
Masahito Takagi, Yasushi Ishigaki, Kenji Uno, Shojiro Sawada, Junta Imai, Keizo Kaneko, Yutaka Hasegawa, Tetsuya Yamada, Ai Tokita, Kazumi Iseki, Shigenori Kanno, Yoshiyuki Nishio, Hideki Katagiri, Etsuro Mori |
Abstract |
Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other neurological diseases, as well as the immune-mediated (type 1) diabetes. GABA is one of the most widely distributed neurotransmitters, but the non-motor symptoms of GADA-positive patients are not well understood. Diabetes is increasingly recognized as a risk factor for dementia; however, the relationship between diabetes and dementia is controversial.The objective of this study was to assess cognitive function in patients with GADA-positive diabetes using subjects with GADA-negative type 2 diabetes as controls. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Egypt | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 70 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 18% |
Researcher | 13 | 18% |
Student > Master | 9 | 13% |
Student > Doctoral Student | 5 | 7% |
Student > Bachelor | 5 | 7% |
Other | 14 | 19% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 29% |
Neuroscience | 10 | 14% |
Psychology | 9 | 13% |
Agricultural and Biological Sciences | 4 | 6% |
Nursing and Health Professions | 4 | 6% |
Other | 10 | 14% |
Unknown | 14 | 19% |