Title |
Disruption of the blood–brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels
|
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Published in |
Journal of Neuroinflammation, July 2013
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DOI | 10.1186/1742-2094-10-80 |
Pubmed ID | |
Authors |
Ya-Jun Li, Zheng-Hai Wang, Bei Zhang, Xiao Zhe, Ming-Jue Wang, Shao-Ting Shi, Jing Bai, Tao Lin, Chang-Jiang Guo, Shi-Jun Zhang, Xiang-Li Kong, Xing Zuo, Hang Zhao |
Abstract |
Increasing evidence suggests seizures cause blood-brain barrier (BBB) dysfunction including decreased seizure threshold and higher onset potential of future seizures. However, the mechanisms underlying BBB damage in seizures remains poorly understood. Evidence in human and animal models shows BBB disruption is associated with activation of matrix metalloproteinase-9 (MMP-9) after cerebral ischemia and inflammation. The objective of this study was to determine whether MMP-9 concentrations in cerebral spinal fluid (CSF) are associated with BBB disruption in patients after epileptic seizures. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Mexico | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 1% |
Netherlands | 1 | 1% |
Ethiopia | 1 | 1% |
Mexico | 1 | 1% |
Russia | 1 | 1% |
Unknown | 62 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 25% |
Researcher | 10 | 15% |
Student > Master | 9 | 13% |
Unspecified | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Other | 11 | 16% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 21% |
Neuroscience | 12 | 18% |
Medicine and Dentistry | 9 | 13% |
Unspecified | 7 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 11 | 16% |
Unknown | 11 | 16% |